Chitosan: a Novel Excipient in Pharmaceutical Formulation: a Review
نویسندگان
چکیده
Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together with chitin, chitosan is well thought-out the second most abundant polysaccharide subsequent to cellulose. But in contrast to cellulose, the application of Chitosan in pharmaceutical field is a pretty new development. Recently there are so many formulation were prepared and evaluated within different dosage forms such as ophthalmic, nasal sublingual, buccal, periodontal, gastrointestinal, colon specific, vaginal, transdermal as well as gene carrier which is based on the application of chitosan and its derivatives. Chitosan is biocompatible and show the activities such as antimicrobial and antifungal activities, which makes it a favourable option for biomedical applications. It has been proven to be useful in tissue growth, in tissue repair and accelerating wound-healing and bone regeneration. Microcrystalline chitosan (MCCh) is a highly crystalline grade of chitosan base may be particularly valuable as an excipient. Mucoadhesive tendency of chitosan might also depend on its crystallinity. Efficient gel formation by MCCh could result in substantial mucoadhesion, at least as far as “adhesion by hydration” is concerned. The objective of this review is to summarized the application and formulation based on the chitosan and its derivatives and also to elaborate the importance of chitosan in pharmaceutical field. INTRODUCTION: Chitosan is a cationic polymer derived from the chitin of crustaceans. Its use in pharmaceutical field has received considerable attention, because it can be obtained from ecologically sound natural sources, namely craband shrimp-shell wastes. However Chitosan has been widely studied in the biomedical field, and has been found to be highly biocompatible . Together with chitin, Chitosan is second most abundant polysaccharide subsequent to cellulose. However contrasting cellulose, the employ of Chitosan as an excipient in pharmaceutical formula is a pretty new development. Now chitosan is available in different grades having difference in their physicochemical properties, and as a base or a salt of a base. This existence of different grades could also be valuable. The properties of chitosan-based dosage forms could be controlled by altering the grade of chitosan in formulations. Chitosan base seems likely to be more useful than chitosan salts in relation to development of slow-release
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